Can the 2020 Ford Fusion make a U-turn?

Yes. Fits a 40 ft street.

37.6ft curb to curb

Street width, feet

Street 40 feet curb to curb.

2020 Ford Fusion S FWD. Top view, to scale.

2020 Ford Fusion: turning circle by trim, 40 ft street
Trim	Circle, ft	Margin	One move
S FWD	37.6	+2.4 ft	Yes
SE FWD	37.6	+2.4 ft	Yes
SE AWD	37.6	+2.4 ft	Yes
SE Hybrid FWD	37.6	+2.4 ft	Yes
SEL FWD	37.6	+2.4 ft	Yes
Hybrid Police Responder FWD	37.6	+2.4 ft	Yes
SEL Hybrid FWD	37.6	+2.4 ft	Yes
Titanium FWD	37.6	+2.4 ft	Yes
Titanium Hybrid FWD	37.6	+2.4 ft	Yes
Titanium AWD	37.6	+2.4 ft	Yes
Plug-in Hybrid Titanium FWD	37.6	+2.4 ft	Yes
Plug-in Hybrid Plug-In Hybrid Titanium FWD	37.6	+2.4 ft	Yes

What this cannot tell you

Curb-to-curb turning circle as listed.

Mirrors and overhang need more room.