What does the 2022 Mercedes-Benz E-Class cost per mile?

Fuel cost a mile

12.3cents

Gas, $ a gallon2025 IRS rate, cents

Gas $3.20. 2025 IRS rate 70 cents.

2022 Mercedes-Benz E-Class E 350 RWD. Cents a mile.

2022 Mercedes-Benz E-Class: cost a mile by trim
Trim	Rating	Cost a mile	Margin a mile	Per 10,000 mi
E 350 RWD	26 mpg	12.3 cents	57.7 cents	$5,769
E 350 4MATIC	24 mpg	13.3 cents	56.7 cents	$5,667
E 350 4MATIC AWD	24 mpg	13.3 cents	56.7 cents	$5,667
E 450 4MATIC AWD	25 mpg	12.8 cents	57.2 cents	$5,720
E 450 RWD	25 mpg	12.8 cents	57.2 cents	$5,720
E 450 4MATIC All-Terrain Wagon	24 mpg	13.3 cents	56.7 cents	$5,667
E 450 RWD Cabriolet	25 mpg	12.8 cents	57.2 cents	$5,720
AMG E 53 Sedan 4MATIC	24 mpg	13.3 cents	56.7 cents	$5,667
E 450 4MATIC Cabriolet AWD	24 mpg	13.3 cents	56.7 cents	$5,667
AMG E 53 Coupe 4MATIC	23 mpg	13.9 cents	56.1 cents	$5,609
AMG E 53 Cabriolet 4MATIC	22 mpg	14.5 cents	55.5 cents	$5,545
AMG E 63 S 4MATIC+ Sedan	24 mpg	13.3 cents	56.7 cents	$5,667
AMG E 63 S 4MATIC+ Wagon	24 mpg	13.3 cents	56.7 cents	$5,667

What this cannot tell you

Fuel only. Insurance, repairs and value loss not counted.

The IRS rate covers every cost, not fuel alone.